| Pos | Team | P | W | D | L | F | A | Diff | Pts |
| 1 | Melbourne City FC | 16 | 10 | 1 | 5 | 38 | 18 | 20 | 31 |
| 2 | Central Coast Mariners | 17 | 9 | 3 | 5 | 27 | 20 | 7 | 30 |
| 3 | Adelaide United | 17 | 9 | 3 | 5 | 31 | 27 | 4 | 30 |
| 4 | Sydney FC | 17 | 7 | 6 | 4 | 23 | 16 | 7 | 27 |
| 5 | Macarthur FC | 18 | 8 | 3 | 7 | 23 | 26 | -3 | 27 |
| 6 | Western Sydney Wanderers | 18 | 6 | 7 | 5 | 27 | 26 | 1 | 25 |
| 7 | Brisbane Roar | 15 | 6 | 5 | 4 | 21 | 17 | 4 | 23 |
| 8 | Western United FC | 15 | 7 | 2 | 6 | 24 | 22 | 2 | 23 |
| 9 | Wellington Phoenix | 17 | 6 | 3 | 8 | 29 | 27 | 2 | 21 |
| 10 | Perth Glory | 16 | 5 | 3 | 8 | 26 | 32 | -6 | 18 |
| 11 | Newcastle Jets | 18 | 3 | 4 | 11 | 16 | 27 | -11 | 13 |
| 12 | Melbourne Victory | 16 | 3 | 2 | 11 | 15 | 42 | -27 | 11 |
| Date | Crowd | Match Type | Match | Notes |
| 18/04/2021 | 9,229 | A-League | Perth Glory 1-3 Wellington Phoenix | Perth Glory have now played 4 matches without a win. |
| 18/04/2021 | 2,854 | A-League | Macarthur FC 2-2 Newcastle Jets | Macarthur FC have now played 3 matches without a win. This is a record non-winning streak for Macarthur FC. |
| Carl Robinson has never coached a team to a win against Ante Milicic. There has been 2 drawn matches and 2 wins to Ante Milicic's team. | ||||
| The crowd of 2,854 was the 4th largest home crowd for Macarthur FC in the history of the A-League. | ||||
| Macarthur FC conceded 1 corner in this match. This is the lowest number of corners they have conceded in a match this season. | ||||
| Newcastle Jets have now played 9 matches without a win. | ||||
| Newcastle Jets had 34.5% ball possession. This is the lowest possession they have had in a match this season. | ||||
| Newcastle Jets had 1 corner in this match. This is the lowest number of corners they have had in a match this season. | ||||
| Newcastle Jets had 65.3% passing accuracy. This is the lowest passing accuracy they have had this season. | ||||
| Newcastle Jets had 6 shots in this match. This is the lowest number of shots they have had in a match this season. | ||||
| 18/04/2021 | N/A | A-League | Sydney FC 2-2 Adelaide United | Sydney FC are now undefeated in their last 4 matches. |
| This match was Kosta Barbarouses's 250th match in the A-League | ||||
| This match was Alexander Baumjohann's 50th match for Sydney FC. | ||||
| Bobo's 2 goals takes his total goals scored against Adelaide United to 6. | ||||
| The last time Adelaide United won when playing away to Sydney FC was over 5 years ago 2/04/2016 Sydney FC 0-2 Adelaide United | ||||
| Steve Corica has never coached a team to a win against Carl Veart. There has been 2 drawn matches and 1 win to Carl Veart's team. | ||||
| Sydney FC had 6 offside calls against them. This is the highest number of offsides they have had in a match this season. | ||||
| Sydney FC conceded 13 corners in this match. This is the highest number of corners they have conceded in a match this season. | ||||
| Adelaide United are now undefeated in their last 3 matches. | ||||
| Adelaide United had 62.2% ball possession. This is the highest possession they have had in a match this season. | ||||
| Adelaide United had 13 corners in this match. This is the highest number of corners they have had in a match this season. | ||||
| Adelaide United had 86.0% passing accuracy. This is the highest passing accuracy they have had this season. | ||||
| 17/04/2021 | N/A | A-League | Melbourne City FC 7-0 Melbourne Victory | Melbourne City FC are now undefeated in their last 3 matches. |
| Jamie Maclaren scored 5 goals in this match. | ||||
| Jamie Maclaren's 5 goals takes his total goals scored against Melbourne Victory to 13. | ||||
| The 7 goal margin was a new record winning margin for Melbourne City FC. | ||||
| The 7 goals scored was a new record for Melbourne City FC. | ||||
| The 7 goal margin was a new record losing margin for Melbourne Victory. | ||||
| The 7 goals conceded was a new record for Melbourne Victory. | ||||
| 17/04/2021 | 3,203 | A-League | Western United FC 1-0 Central Coast Mariners | The crowd of 3203 was the 5th smallest home crowd for Western United FC in the history of the A-League. |
| 16/04/2021 | 8,251 | A-League | Western Sydney Wanderers 1-2 Brisbane Roar | Western Sydney Wanderers have now played 5 matches without a win. |
| Western Sydney Wanderers have not won in the last 4 matches when they have hosted Brisbane Roar | ||||
| Carl Robinson has never coached a team to a win against Warren Moon. There has been 2 drawn matches and 2 wins to Warren Moon's team. | ||||
| Brisbane Roar are now undefeated in their last 4 matches. | ||||
| Western Sydney Wanderers have not beaten Brisbane Roar in the last 5 matches between these two teams. |
| Date | Match | Notes |
| 22/04/2021 | Western United FC vs. Wellington Phoenix | The last time these teams played was on 11/04/2021, the result was Wellington Phoenix 3-2 Western United FC. |
| 23/04/2021 | Melbourne Victory vs. Western Sydney Wanderers | The last time these teams played was on 10/02/2021, the result was Western Sydney Wanderers 2-0 Melbourne Victory. |
| Melbourne Victory have never failed to score a goal when playing at home against Western Sydney Wanderers | ||
| Western Sydney Wanderers have not had a win in their last 5 matches. | ||
| 24/04/2021 | Central Coast Mariners vs. Sydney FC | The last time these teams played was on 22/01/2021, the result was Sydney FC 0-2 Central Coast Mariners. |
| The last time these teams played was the first time in the last 7 matches between the two that Central Coast Mariners has managed to beat Sydney FC. | ||
| Central Coast Mariners have not won in the last 3 matches when they have hosted Sydney FC | ||
| Sydney FC are currently undefeated in their last 4 matches. | ||
| 24/04/2021 | Macarthur FC vs. Melbourne City FC | The last time these teams played was on 12/03/2021, the result was Melbourne City FC 3-0 Macarthur FC. |
| Macarthur FC have not had a win in their last 3 matches. This is a record non-winning streak for Macarthur FC. | ||
| Melbourne City FC are currently undefeated in their last 3 matches. | ||
| 25/04/2021 | Brisbane Roar vs. Perth Glory | The last time these teams played was on 26/02/2021, the result was Perth Glory 3-1 Brisbane Roar. |
| Brisbane Roar have not beaten Perth Glory in the last 6 matches between these two teams. | ||
| Brisbane Roar are currently undefeated in their last 4 matches. | ||
| Perth Glory have not had a win in their last 4 matches. | ||
| 25/04/2021 | Wellington Phoenix vs. Adelaide United | The last time these teams played was on 25/07/2020, the result was Wellington Phoenix 1-1 Adelaide United. |
| Adelaide United are currently undefeated in their last 3 matches. | ||
| 27/04/2021 | Sydney FC vs. Melbourne Victory | The last time these teams played was on 4/04/2021, the result was Melbourne Victory 0-3 Sydney FC. |
| Melbourne Victory have not beaten Sydney FC in the last 6 matches between these two teams. |
| Pos | Team | P | W | D | L | F | A | Diff | Pts |
| 1 | Adelaide United | 8 | 6 | 1 | 1 | 14 | 7 | 7 | 19 |
| 2 | Melbourne City FC | 7 | 6 | 0 | 1 | 22 | 7 | 15 | 18 |
| 3 | Western United FC | 8 | 5 | 2 | 1 | 13 | 7 | 6 | 17 |
| 4 | Central Coast Mariners | 9 | 5 | 2 | 2 | 15 | 11 | 4 | 17 |
| 5 | Sydney FC | 10 | 4 | 4 | 2 | 11 | 9 | 2 | 16 |
| 6 | Macarthur FC | 9 | 3 | 3 | 3 | 14 | 13 | 1 | 12 |
| 7 | Wellington Phoenix | 10 | 3 | 2 | 5 | 17 | 16 | 1 | 11 |
| 8 | Western Sydney Wanderers | 9 | 3 | 2 | 4 | 15 | 14 | 1 | 11 |
| 9 | Perth Glory | 6 | 3 | 1 | 2 | 13 | 11 | 2 | 10 |
| 10 | Brisbane Roar | 7 | 2 | 3 | 2 | 10 | 8 | 2 | 9 |
| 11 | Melbourne Victory | 8 | 2 | 0 | 6 | 9 | 21 | -12 | 6 |
| 12 | Newcastle Jets | 9 | 1 | 1 | 7 | 7 | 16 | -9 | 4 |
| Pos | Team | P | W | D | L | F | A | Diff | Pts |
| 1 | Macarthur FC | 9 | 5 | 0 | 4 | 9 | 13 | -4 | 15 |
| 2 | Brisbane Roar | 8 | 4 | 2 | 2 | 11 | 9 | 2 | 14 |
| 3 | Western Sydney Wanderers | 9 | 3 | 5 | 1 | 12 | 12 | 0 | 14 |
| 4 | Melbourne City FC | 9 | 4 | 1 | 4 | 16 | 11 | 5 | 13 |
| 5 | Central Coast Mariners | 8 | 4 | 1 | 3 | 12 | 9 | 3 | 13 |
| 6 | Sydney FC | 7 | 3 | 2 | 2 | 12 | 7 | 5 | 11 |
| 7 | Adelaide United | 9 | 3 | 2 | 4 | 17 | 20 | -3 | 11 |
| 8 | Wellington Phoenix | 7 | 3 | 1 | 3 | 12 | 11 | 1 | 10 |
| 9 | Newcastle Jets | 9 | 2 | 3 | 4 | 9 | 11 | -2 | 9 |
| 10 | Perth Glory | 10 | 2 | 2 | 6 | 13 | 21 | -8 | 8 |
| 11 | Western United FC | 7 | 2 | 0 | 5 | 11 | 15 | -4 | 6 |
| 12 | Melbourne Victory | 8 | 1 | 2 | 5 | 6 | 21 | -15 | 5 |
| Pos | Player | Team | Goals |
| 1 | Jamie Maclaren | Melbourne City FC | 19 |
| 2 | Matt Derbyshire | Macarthur FC | 11 |
| 3 | Bruno Fornaroli | Perth Glory | 8 |
| 4 | Ulises Davila | Wellington Phoenix | 7 |
| Besart Berisha | Western United FC | 7 | |
| Tomi Juric | Adelaide United | 7 | |
| Dylan Wenzel-Halls | Brisbane Roar | 7 | |
| Alou Kuol | Central Coast Mariners | 7 | |
| Matt Simon | Central Coast Mariners | 7 | |
| 10 | Stefan Mauk | Adelaide United | 6 |
| Riku Danzaki | Brisbane Roar | 6 | |
| Kosta Barbarouses | Sydney FC | 6 | |
| Bobo | Sydney FC | 6 |